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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Neuroscience. 2019 Mar 26;406:528–541. doi: 10.1016/j.neuroscience.2019.03.040

Figure 5: Chronic NAC during extinction or acute activation of GFAP-hM3D in NAcore suppresses cue-induced methamphetamine seeking.

Figure 5:

A) Akin to what has been observed with other drugs of abuse, NAC treatment significantly reduced cued responding during methamphetamine reinstatement, p<0.01 B) Shown on the left is an atlas plate with a red square depicting the localization of the inset panel on the right. The micrograph shows a field of Gq-DREADD transduced astrocytes at low magnification (scale bar represents 100 microns). The inset panel depicts a higher magnification image of an individual cell within the low magnification plane to confirm the non-neuronal cellular identity of the transduced cell consistent with our previous reports (Scofield et al., 2015b). C) CNO significantly reduced active lever pressing during cued methamphetamine reinstatement when compared to vehicle controls **p<0.01 compared to vehicle.