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. 2019 Apr 30;22(6):372–382. doi: 10.1093/ijnp/pyz008

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© The Author(s) 2019. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Hippocampus-specific knockdown of peroxisome proliferator-activated receptor δ (PPARδ) decreased hippocampal neurogenesis and neuronal differentiation in mice. (A) Representative micrographs and (B) quantification of 5-Bromo-2’-Deoxyuridine (BrdU)-labeled cells (red) in the dentate gyrus (DG) of the mice. (C) Representative micrographs of cells double-labeled for BrdU (red, left) and the neuronal marker NeuN (green, middle). (D) Percentages of neurons labeled by BrdU in the DG of the mice injected with LV-EGFP or LV-PPARδ-shRNA-EGFP. (E) Representative micrographs of cells double-labeled for BrdU (red, left) and the astrocyte marker glial fibrillary acidic protein (GFAP) (green, middle). (F) Percentages of glial cells labeled by BrdU in the DG of the mice injected with LV-EGFP or LV-PPARδ-shRNA-EGFP. Data shown are mean ± SEM; n = 6. *P < .05, **P < .01 vs control.