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. 2019 Apr 30;22(6):372–382. doi: 10.1093/ijnp/pyz008

Figure 5.

Figure 5.

Knockdown of peroxisome proliferator-activated receptor δ (PPARδ) decreased the production of mBDNF and the phosphorylation of cAMP-response element binding protein (CREB). The protein levels of (A) mBDNF and pro-BDNF, (B) pCREP and CREB in the hippocampus DG of the mice were detected by western blot using respective antibodies; β-actin was used loading control. Relative expression of mBDNF/control or pCREP/CREB was quantified by densitometric analysis. (C) The mBDNF and pro-BDNF and (D) pCREB and CREB were detected by western blot using respective antibodies in the neural stem cells (NSCs) maintained in proliferation or differentiation medium; β-actin was used loading control, and relative expression of mBDNF/control or pCREP/CREB was quantified by densitometric analysis. Data are shown as mean ± SEM; n = 6. *P < .05, **P < .01 vs control.