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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Neuroscience. 2019 Mar 16;406:314–324. doi: 10.1016/j.neuroscience.2019.03.020

Figure 4: Chemoactivation of MCH neurons specifically increases REMs.

Figure 4:

Percentages of time spent in wake, NREMs and REMs (A, D, G), as well as number of bouts (B, E, H) and mean bout duration (C, F, I) during the 3 h recording period after saline (white bars) or CNO (black bars) injections in MCH-Cre mice (n = 9). Saline or CNO (0.3 mg/kg, i.p.) was administered at ZT6 and sleep-wake recordings were conducted between ZT7-ZT10. CNO injections specifically increased the amount of REMs (p=0.0021, 2-tailed paired t-test) and the number of REMs bouts (p=0.0106, 2-tailed paired t-test) without affecting other stages. Data are Mean ± SEM; * P < 0.05, ** P < 0.01.