. 2019 Jun 3;20:200. doi: 10.1186/s12882-019-1342-x

Table 2.

Effect of hypertonic saline and furosemide on plasma concentrations of electrolytes in a randomized, cross-over study of 24 healthy subjects

Period	Baseline (90 min)	After 60 min hypertonic saline infusion (150 min)	90 min post hypertonic saline infusion (240 min)	P-value (difference in response)
p-Na (mmol/L)
Placebo	140 ± 2	144 ± 2^*	141 ± 2^*	0.073
Furosemide	139 ± 2	144 ± 2^*	141 ± 2^*	0.073
p-K (mmol/L)
Placebo	3.8 ± 0.2	3.7 ± 0.2^*	4.0 ± 0.2^*	0.001
Furosemide	3.7 ± 0.2	3.5 ± 0.2^{*, †}	3.8 ± 0.2^†	0.001
p-Cl(mmol/L)
Placebo	105 ± 2	111 ± 2^*	107 ± 2^*	< 0.001
Furosemide	104 ± 2	108 ± 2^{*, †}	104 ± 2^{*, †}	< 0.001
p-Osmolality (mmol/L)
Placebo	282 ± 4	289 ± 3^*	286 ± 4^*	0.034
Furosemide	282 ± 3	291 ± 3^{*, †}	286 ± 3^*	0.034
p-total carbondioxide (mmol/L)
Placebo	27 ± 2	25 ± 2^*	25 ± 2^*	< 0.001
Furosemide	26 ± 2	26 ± 2^†	27 ± 2^†	< 0.001

p-Na Plasma concentrations of sodium, p-K potassium, p-Cl chloride and total carbondioxide and plasma osmolality were measured every 30 min during examination. Data show are values before hypertonic saline infusion, after 60 min of saline infusion, and 90 min after cessation of saline infusion on the examination day. Data are shown as medians with 25 and 75 percentiles in brackets. P-value represents probability of difference in response to saline (response from baseline to saline infusion) between treatments. To test difference in response to saline between treatments a students t-test was used. Wilcoxon signed rank test was performed to test differences from baseline, * = p < 0.05, and from Placebo, ^† = p < 0.05