Fig. 1.
Correlation between gene expression, glucose and insulin homeostasis. Pearson correlation plots between log2 gene expression values of key lipogenic genes and HbA1c (a-c) or HOMA2-IR (d-f) are shown. Genes are fatty acid elongase-6 (ELOVL6), stearoyl-CoA desaturase (SCD) and fatty acid synthase (FASN). Liver samples from non-statin treated patients (n = 747) are indicated as blue dots, liver samples from statin-treated patients (n = 173) are indicated as red dots. The following correlation coefficients and P values were calculated for HbA1c: ELOVL6: r = 0.23, P = 7.2 × 10− 12; SCD: r = 0.24, P = 3.9 × 10− 13; FASN: r = 0.26, P = 3.3 × 10− 15. The following correlation coefficients and P values were calculated for HOMA2-IR: ELOVL6: r = 0.11, P = 2.9 × 10− 03; SCD: r = 0.11, P = 2.0 × 10− 03; FASN: r = 0.21, P = 1.6 × 10− 09. Abbreviations: HbA1c: hemoglobin A1c, HOMA2-IR: homeostasis model assessment of insulin resistance