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. 2019 Jun 3;16:22. doi: 10.1186/s12989-019-0307-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effect of NP on expression of genes related to ROS regulation in BrainSpheres. Graphs showing the relative expression of SOD1, SOD2, NF2L2, GSTO1, NFR1 and CLEC7A after exposure to Au-SC (6 μg/mL), Au-PEG (20 μg/mL) and PLA-NP (20 μg/mL) for 72 h normalized to the expression of the genes in the untreated control spheroids. Data was collected from three independent experiments and represents fold changes (FC ± SEM, n = 3). One-way ANOVA with Bonferroni’s multiple comparisons post-test was used to analyze the statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001)