Table 1.

Gene Ontology (GO) results of the hyper-methylated sites

ID	Description	Number of genes (intersection/ total)	Significance (p-value, FDR)
GO:0008283	The multiplication or reproduction of cells, resulting in the expansion of a cell population.	50 / 263	0, 0
GO:0016338	The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.	6 / 13	0, 0
GO:0071364	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.	12 / 33	0.004, 0.019

ID: GO ID, Description: GO Term description, Number of genes: “total” is the number of genes that are mapped in the 450 K bead array in the GO term, “intersection” means the number of genes that have associations with the selected hyper-methylated sites among the total, Significance: “p-value” was obtained from permutation test, “FDR” is False Discovery Rate (see materials and methods)