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. 2019 Jun 3;20:298. doi: 10.1186/s12859-019-2906-2

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Overview of the first three steps of BrownieCorrector’s pipeline. Read pairs for which one read contains a highly repetitive k-mer are extracted and clustered based on the sequence similarity between different read pairs. Each cluster is expected to contain reads that were derived from a single genomic regions