Figure 4.
Effects of ADSC transplantation on HFD-induced disorders in glucose metabolism. Intraperitoneal GTT (a) and ITT (c) results obtained four weeks after the transplantation, (e, g) intraperitoneal GTT (e) and ITT (g) results obtained eight weeks after the transplantation. The area under the curve (AUC) for the IPGTT results was calculated using the blood glucose levels at 0 (BG0), 30 (BG30), 60 (BG60), 90 (BG90), and 120 (BG120) minutes by the following equation: AUC (min mg/dL) =30 min × (1/2 × [BG0 + BG120] + 1 × [BG30 + BG60 + BG90]); *: compare with HFD, ***P < 0.001; #: compare with ADSCs, ###P < 0.01. ADSCs – HFD-fed mice with ADSC infusion; HFD – HFD-fed mice without cell infusion; Nrg4-ADSC – HFD-fed mice with Nrg4-ADSC infusion. ADSC: adipose tissue-derived MSC; HFD: high-fat diet; Nrg4: neuregulin 4.