Table 4.
Stepwise-forward multivariate analysis on risk factors for treatment failure at D30.
| Dependent variable: treatment failure at day 30 | ||||
|---|---|---|---|---|
| Univariate |
Multivariate (only remaining variables) |
95% confidence interval | ||
| Variable | p-value | p-value | odds ratio | |
| Age | 0.001 | 0.001 | 1.060 | 1.025–1.097 |
| Gender | 0.546 | |||
| ECOG status | 0.144 | |||
| Immunosuppression | 0.093 | |||
| Ribotype 027 | 0.766 | |||
| Severe CDI | 0.374 | 0.083 | 0.311 | 0.083–1.166 |
| Number of recurrences | 0.054 | 0.080 | 1.477 | 0.955–2.284 |
| Antibiotic induction | 0.688 | |||
| Proton pump inhibitor | 0.114 | |||
| Antimotility agent | 0.925 | |||
| Bowel lavage | 0.191 | |||
| Frozen FMT preparation | 0.283 | |||
| Route of application | ||||
| Capsules | 0.093 | |||
| Upper GIT | 0.214 | |||
| Lower GIT | 0.254 | |||
CDI = Clostridioides difficile infection, ECOG = Eastern Cooperative Oncology Group, FMT = fecal microbiota transfer, GIT = gastrointestinal tract.