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. 2019 May 20;2019:9747212. doi: 10.1155/2019/9747212

Figure 1.

Figure 1

A high-fat diet promotes the establishment of atherosclerosis (AS) in ApoE −/− mice. (a). Serum levels of glucose, total cholesterol, triglyceride, LDL-C, and HDL-C in C57BL/6J mice fed a normal diet and in ApoE−/− mice fed a normal or high-fat diet. Each group contained six mice. (b) Oil red O staining of aorta (A, B, and C) and aortic arch (D, E, and F). A and D: C57BL/6J mice with normal diet; B and E: ApoE−/− mice fed a normal diet; C and F: ApoE−/− mice administered a high-fat diet. Red arrows indicate the aortic arch and aortic staining sites. (c) The percentage of splenic Treg and Th17 cells, as detected by flow cytometry. The data are presented as means ± SEM. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ∗∗∗∗P < 0.0001; results were considered statistically significant at P < 0.05.