Table 2.
Details of nsSNPs selected as deleterious among the reported SNPs, their conservation analysis by ConSurf, and posttranslational modification site prediction by ModPred.
| Position | Conservation score | B/E | F/S | PTM sites (wild type) | Variants | PTM sites (mutants) |
|---|---|---|---|---|---|---|
| I32 | 7 | B | — | — | I32S | — |
| C51 | 9 | B | S | — | C51Y | Amidation Phosphorylation |
| G58 | 9 | E | F | Proteolytic cleavage | G58R | Proteolytic cleavage |
| G58E | Proteolytic cleavage | |||||
| G66 | 7 | E | — | Proteolytic cleavage | G66R | Proteolytic cleavage |
| G71 | 4 | B | — | — | G71R | Proteolytic cleavage ADP-ribosylation |
| C74 | 9 | B | S | Disulfide linkage | C74W | — |
| C78 | 9 | B | S | Disulfide linkage | C78S | O-linked glycosylation |
| G79 | 9 | E | F | — | G79C | Disulfide linkage |
| R84 | 6 | E | — | ADP-ribosylation Proteolytic cleavage |
R84C | Disulfide linkage |
| D97 | 9 | E | F | — | D97E | Disulfide linkage |
| W98 | 8 | B | — | C-linked glycosylation Proteolytic cleavage Amidation |
W98C | Disulfide linkage |
| W98L | — | |||||
| C103 | 9 | B | S | Disulfide linkage | C103 | Proteolytic cleavage |
| C104 | 9 | B | S | Disulfide linkage | C104 | Amidation Proteolytic cleavage |
PTM: posttranslational modification; B: buried; E: exposed; F: functional; S: structural.