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. 2019 May 20;2019:4951627. doi: 10.1155/2019/4951627

Table 3.

Prediction of change in protein stability using I-Mutant2.0 and MUpro.

Position I-Mutant2.0 MUpro
DDG value (kcal/mol) DDG value SVM NN (kcal/mol)
I32S -2.45 (decrease) -1.490 (decrease) -0.80 (decrease) -0.96 (decrease)
C51Y -0.89 (decrease) -0.234 (decrease) -0.20 (decrease) -0.69 (decrease)
G58R -0.15 (decrease) -0.95 (decrease) -0.22 (decrease) -0.73 (decrease)
G58E -1.43 (decrease) -0.913 (decrease) 0.23 (increase) -0.67 (decrease)
G66R -1.74 (decrease) -0.84 (decrease) 0.48 (increase) 0.51 (increase)
C74W -0.76 (decrease) -0.69 (decrease) 0.54 (increase) 0.85 (increase)
C78S -0.63 (decrease) -1.513 (decrease) -0.09 (decrease) 0.87 (increase)
G79C -0.89 (decrease) -0.842 (decrease) -0.84 (decrease) -0.38 (decrease)
D97E 0.52 (increase) -0.77 (decrease) 0.025 (increase) -0.65 (decrease)
W98C -1.14 (decrease) -0.442 (decrease) -0.77 (decrease) -0.92 (decrease)
W98L -0.59 (decrease) 0.16 (increase) -0.10 (decrease) 0.691 (increase)
C103G -1.05 (decrease) -1.63 (decrease) -0.80 (decrease) 0.547 (increase)
C104Y 0.32 (increase) -1.03 (decrease) -0.36 (decrease) -0.80 (decrease)

DDG: delta delta G; SVM: support vector machine; NN: neural network.