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. 2019 Jan 24;104(6):1189–1201. doi: 10.3324/haematol.2018.202044

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Figure 6. — Transcriptional transition towards a hematopoietic/endothelial gene signature in double fusion-expressing hemato-endothelial precursors. (A) Heatmap representation of hierarchical clustering of genes differentially expressed between empty vector (EV)-, single fusions- and double fusion-expressing hemato-endothelial precursors (HEP). Each column represents a technical replicate from three independent experiments. (B,C) Statistically significant functional categories (B) and cancer/leukemia-associated biofunctions (C) identified using Ingenuity Pathway Analysis on genes differentially expressed in single fusions-, and double fusion-expressing HEP relative to EV. They are ranked by z-score. Functional categories associated with “hematological system development and function” and “cardiovascular system development” are shown in bold. All significant biofunctions are associated with blood cell differentiation, homeostasis and migration/movement.