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. Author manuscript; available in PMC: 2019 Jun 3.
Published in final edited form as: ALTEX. 2018 Feb 23;35(3):306–352. doi: 10.14573/altex.1712081

Figure 7: Incorporation of potential endocrine effects into an IATA for DNT hazard identification/characterization.

Figure 7:

Before applying the IATA it would be important to determine whether any DNT hazard could potentially be due to an endocrine mediated mode of action. Assays and models are in place (or under development) for regulatory purposes (for estrogen, androgen, steroid and thyroid (EATS) modalities). For the regulatory decision making, any further characterization of DNT effects by the proposed IATA should be integrated with the EATS information. IATA: integrated approach to testing and assessment; DNT: developmental toxicity; QSAR: quantitative structure activity relationship; ADME: absorption, distribution, metabolism and excretion; AOP: adverse outcome pathway.

AOP 12: https://aopwiki.org/aops/12

AOP 13: https://aopwiki.org/aops/13

AOP 42: https://aopwiki.org/aops/42

AOP 54: https://aopwiki.org/aops/54