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. 2018 Aug 1;24(6):357–365. doi: 10.1177/1753425918791024

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — LPS-stimulated increase in macrophage Mmp10 expression is dependent on type I IFN. Wild-type (WT) and Ifnar1^−/− BMDMs were stimulated with PBS (control), LPS (10 ng/ml), or poly(I:C) (10 μg/ml) and mRNA levels of Mmp8, Mmp9, Mmp10, and Mmp12 relative to Hprt were measured at 4 h. LPS-induced Mmp10 expression was dependent on IFNAR1; however, poly(I:C) did not increase Mmp10 expression. LPS or poly(I:C) did not increase Mmp8, Mmp9, or Mmp12. Data represent mean ± SEM from five to six mice/genotype. Statistical analyses used two-way ANOVA with Sidak's multiple-comparisons test between WT and Ifnar1^−/− samples and Tukey's multiple-comparisons test to compare treatment groups within each genotype. ***P < 0.001; ns, or otherwise not indicated, are not significant (P > 0.05).