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. 2019 May 24;10:1162. doi: 10.3389/fimmu.2019.01162

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Copyright © 2019 Buhl and Wenzel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receptor signaling pathway and recruitment of IL-1RAcP. Pathways that are activated by IL-36 cytokines via IL-36 receptor (IL 1Rrp2 /IL results in the γ, and IL 36β, IL 36α1R6). TThe binding of IL-36 activation of pro-inflammatory mediators. The binding of the anti-inflammatory ligand IL 36 Ra prevents the recruitment of IL 1 receptor accessory protein (IL-1RAcP) and the pro-inflammatory cascade is absent. TIR, Toll/Interleukin 1 receptor; MyD88, myeloid differentiation primary response 88; IRAKs, interleukin-1 receptor-associated kinases; NFB, nuclear factor “kappa-light-chain-enhancer” of activated B-cells; AP 1, activator protein 1.