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. 2019 May 24;10:1162. doi: 10.3389/fimmu.2019.01162

Figure 2.

Figure 2

Deficiency of IL-36 Ra (DITRA). Pro-inflammatory IL-36α, IL-36β, and IL-36γ bind constitutively to the receptor inducing the signaling cascade without being regulated by anti-inflammatory IL-36 Receptor antagonist. Deficiency of IL-36 Ra (DITRA); generalized pustular psoriasis (GPP).