Figure 7.

Non-human primate (NHP) LCs targeted through langerin promote antibody responses, but fail to induce CD8⁺ T cell responses. (A) Animals were bled at the indicated time points and the serum anti-Gag levels determined by ELISA. Vertical dotted lines indicate the time of immunizations. (B) Gag-specific IFNγ ELISpot results on PBMCs harvested at the indicated time points are shown. Vertical dotted lines indicate the time of immunizations. Horizontal dot line indicates background level. On the right, positive controls for the ELISpot assay. *p < 0.05.