Figure 1.

Microinjection of kainic acid (KA) into the amygdala produces frequent, chronic behavioral temporal lobe seizures. A, Top: Representative electroencephalography (EEG) trace during a behavioral (Racine stage V) seizure recorded with a hippocampal depth electrode, 21 weeks after KA injection. Bottom: Numbered and outlined regions of the top trace are enlarged to show detail, in respective numbered boxes. Scale bars: Top—5 s, 500 μV; Box 1—100 msec, 5 μV, Box 2—100 msec, 250 μV, Box 3—100 msec, 250 μV. B, C, Summary plots demonstrate the total number of seizures per day (B) and the mean length of a single seizure (C) in each individual mouse, for the 5 days preceding the in vivo juxtacellular recordings. These graphs refer only to Racine class V, generalized tonic‐clonic seizures. Color legend refers to panels B and C. Note that these graphs only include data from epileptic mice with 5 days of reliable EEG recordings. None of the control mice demonstrated any seizures