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. 2019 Jun 1;33(11-12):705–717. doi: 10.1101/gad.322453.118

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© 2019 Jiang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 8. — Model of how Ccr4–Not promotes Rpb1 ubiquitylation. Ccr4–Not promotes the recruitment of Rsp5 (E3) and Ubc4 (E2) through its RING domain to the core of RNAPII to position the E2–E3 pair and direct the ubiquitylation of Rpb1.