Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 1;33(11-12):626–640. doi: 10.1101/gad.324467.119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Li et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 7. — Twist2 dynamically regulates global chromatin organization during differentiation. (A, left) Heat map depicting differential binding of Twist2 in GM versus DM conditions and the effect on H3K27ac and H3K27me3. (Right) ChIP signal distribution plot of Twist2, H3K27ac, and H3K27me3 peaks associated with up-regulated and down-regulated Twist2 peaks in DM versus GM conditions. (B) Scatter plot depicting differential binding of H3K27ac in the presence and absence of Twist2 in DM. Differential binding cutoff was set at a twofold or greater change and P_adj < 0.05. (C, left) Heat map depicting the effect of Twist2 on differential binding of MyoD and H3K27ac. (Right) ChIP signal distribution plot of Twist2, MyoD, and H3K27ac peaks associated with up-regulated and down-regulated MyoD peaks in TW2-DM versus GFP-DM. (D, left) Heat map depicting the effect of Twist2 on differential binding of MyoD and H3K27me3. (Right) ChIP signal distribution plot of TWIST2, MyoD, and H3K27me3 peaks associated with up-regulated and down-regulated MyoD peaks in TW2-DM versus GFP-DM. (E) Genome browser shot depicting H3K27ac and H3K27me3 changes at the Mymk locus during differentiation in the presence and absence of Twist2. (F) GREAT analysis of H3K27ac peaks down-regulated in TW2-DM versus GFP-DM. (G) Genome browser shot depicting gain of H3K27ac and MyoD peaks in the Notch3 locus upon Twist2 binding. (H) GREAT analysis of H3K27ac peaks up-regulated in TW2-DM versus GFP-DM.