. Author manuscript; available in PMC: 2019 Oct 1.

Published in final edited form as: Eur J Haematol. 2018 Aug 31;101(4):532–541. doi: 10.1111/ejh.13140

Table 3.

Factors associated with exercise capacity among participants in the CSSCD

Variable	N	Low Fitness Tertile (N=74)	Intermediate Fitness Tertile (N=84)	High Fitness Tertile (N=65)	p value^*
Age (years), mean±SD	223	45.2 ±8.2	43.1 ±7.5	41.3 ±6.0	0.007
SS or S/β⁰ thalassemia, number (%)	222	58 (79.5)	55 (66.3)	41 (63.1)	0.078
Male sex, number (%)	223	17 (23)	24 (28.6)	39 (60)	< 0.001
Baseline haemoglobin (g/dL), mean±SD	223	8.5 ±2.1	9.0 ±2.1	9.8 ±2.2	0.003
Baseline WBC (x10³/ml), mean±SD	223	11.5 ±4.3	10.6 ±3.4	10.3 ±3.5	0.139
BMI at fitness test, mean±SD	194	25.1 ±7.1	25.2 ±5.8	23.3 ±4.6	0.111
Duration on treadmill (min), mean±SD	223	5.7 ±1.9	11.8 ±1.6	18.1 ±2.1	< 0.001
Peak incline, mean±SD	208	5.4 ±2.6	12.5 ±2.2	19.8 ±2.8	< 0.001
METS, mean±SD	208	4.0 ±0.7	6.0 ±0.6	8.0 ±0.8	< 0.001
Abnormal PFT, number (%)	220	42 (58.3)	29 (34.9)	25 (38.5)	0.008
Pain hospitalization rate, 3 year retrospective, mean±SD	223	0.38 ±0.00	0.33 ±0.00	0.31 ±0.00	0.630^#
ACS hospitalization rate, 3 year retrospective, mean±SD	223	0.03 ±0.00	0.06 ±0.00	0.03 ±0.00	0.426^#

ACS: acute chest syndrome; BMI: body mass index; METS: Metabolic Equivalent of Task; PFT: pulmonary function test; SD: standard deviation; WBCs: white blood cells

^{^}

Exercise capacity defined by the duration on treadmill in minutes

ANOVA for comparing means and chi-square test for comparing percentages, unless otherwise noted

Kruskal-Wallis test