. Author manuscript; available in PMC: 2020 Mar 1.

Published in final edited form as: Mayo Clin Proc. 2019 Jan 31;94(3):536–543. doi: 10.1016/j.mayocp.2018.11.016

Table 1.

Effect of androgens

	Obese males with androgen supplements	Females with increased endogenous androgens

Food intake	Decreased⁸	Increased⁴
Body weight	Decreased⁸	Increased⁴
Activity	Increased⁸	?
Plasma Lipids	decreased⁸	Increased⁴
Inflammatory mediators (TNFα)	Decreased⁸	Increased⁴
Sympathetic nervous system activation	?	Increased¹⁷
Renal nerve activation	?	Increased¹⁷
Melanocortin-4 receptor activation	?	Increased¹⁷
RAS activation	?	? ⁴
Increased renal microvascular 20-HETE	?	Increased²⁴
Increased oxidative stress	?	Increased⁴
Blood pressure	Increased⁸	increased^4,17,24

Abbreviations: RAS = renin-angiotensin system; TNFα = tumor necrosis factor-alpha. Numbers are the references cited.