Table 1.
Baseline characteristics (N = 796)
| Characteristic | Adenocarcinoma n = 780 |
Adenosquamous carcinoma n = 16 |
|
|---|---|---|---|
| N (%) | N (%) | P | |
| Host characteristics | |||
| Age | |||
| Median, y | 65 | 61 | 0.1826 |
| Gender | |||
| Male | 695 (89%) | 10 (63%) | 0.0061 |
| Female | 85 (11%) | 6 (37%) | |
| Body mass index | |||
| Normal | 263 (34%) | 10 (63%) | 0.0203 |
| Excess | 517 (66%) | 6 (37%) | |
| Smoking | |||
| Ever | 193 (25%) | 4 (25%) | 0.9813 |
| Never | 587 (75%) | 12 (75%) | |
| Tumor characteristics | |||
| T stage | |||
| T1-T2 | 288 (37%) | 4 (25%) | 0.3027 |
| T3-T4 | 486 (63%) | 12 (75%) | |
| Missing | 4 | 0 | |
| No. metastatic LNs | |||
| Median | 2 | 2.5 | 0.1731 |
| Histologic grade | |||
| 1 to 3 | 469 (61%) | 8 (50%) | 0.3785 |
| 4 | 300 (39%) | 8 (50%) | |
| Missing | 11 | 0 | |
| Adjacent Barrett’s | |||
| Yes | 277 (36%) | 5 (31%) | 0.7216 |
| No | 503 (64%) | 11 (69%) | |
| Tumor location | |||
| Esophagus | 277 (36%) | 6 (38%) | 0.8729 |
| GEJ or cardia | 502 (64%) | 10 (63%) | |
| HER2 statusᵅ | |||
| Positive | 121 (17%) | 0 | 0.0175 |
| Negative | 577 (83%) | 15 (100%) | |
| Missing | 82 | 1 | |
ᵅ
HER2-positive defined as strong protein expression (IHC 3+) or equivocal expression (IHC 2+) with gene amplification
P <.05 is bolded.
IHC, immunohistochemistry.