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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Nitric Oxide. 2018 Dec 24;83:51–64. doi: 10.1016/j.niox.2018.12.007

Figure 6. Roles of GSNO and FeTPPS on BBB leakage, edema and the expression of 3-NT in TBI rat model.

Figure 6.

A. Photographs showing Evan’s blue (EB) extravasations in brain starting at 4 hr after TBI. Animals were sacrificed at 24 hr, the brain was photographed (i) and the intensity of EB (ii) was determined by spectrofluorometric estimation. EB extravasations were not observed in sham brain. B. Edema (tissue water content) was measured at 24 hr after TBI. C. The levels of nitrotyrosine (N-Tyr) as an index of ONOO− were also measured at 24 hr in the traumatic penumbra region using Western and its quantitation by densitometry. Data are expressed as mean ± standard deviation from five different experiments for Evan’s blue and edema each and three different experiments for western blot. * p ≤ 0.05, *** p ≤ 0.001 vs. Sham and + p ≤ 0.05, ++ p ≤ 0.01, and +++ p ≤ 0.001 vs. TBI.