Table 3.

Clinical outcomes at 3 years in the ACEI and ARB group in prespecified subgroups*

	ACEI rate % (95% CI)	ARB rate % (95% CI)	HR (95% CI)†	Interaction p value
Age (years)
<75	10.3 (9.8 to 10.7)	10.1 (9.4 to 10.8)	1.02 (0.93 to 1.12)	0.155
≥75	20.4 (19.9 to 20.9)	18.8 (18.0 to 19.6)	1.10 (1.04 to 1.17)
Sex
Female	18.0 (17.4 to 18.6)	15.6 (14.7 to 16.5)	1.17 (1.10 to 1.26)	<0.001
Male	14.6 (14.1 to 15.0)	14.7 (14.0 to 15.4)	1.00 (0.93 to 1.06)
Prior diabetes
Yes	18.9 (18.4 to 19.5)	18.1 (17.2 to 19.0)	1.05 (0.99 to 1.12)	0.576
No	13.5 (13.0 to 14.0)	12.6 (11.9 to 13.3)	1.08 (1.01 to 1.17)
Prior heart failure
Yes	28.7 (27.8 to 29.6)	26.4 (25.1 to 27.8)	1.12 (1.04 to 1.20)	0.209
No	11.7 (11.4 to 12.1)	11.2 (10.7 to 11.8)	1.05 (0.98 to 1.12)

*Primary outcome defined as cardiovascular death, rehospitalisation for myocardial infarction and unstable angina.

†ARB inhibitor was the reference group.

ACEI, ACE inhibitor; ARB, angiotensin receptor blocker.