TABLE 2.
HMOs1
| Infant age | |||
| HMO | 1 mo, μg/mL | 6 mo, μg/mL | Change, μg/mL |
| 2′-FL | 2750.0 (3738.7) | 2430.9 (2798.8) | −13.5 (932.5) |
| 3-FL2 | 162.7 (130.2) | 515.7 (439.1) | 291.0 (229.9)‡ |
| 3′-SL2 | 756.3 (432.1) | 1125.4 (284.3) | 408.4 (400.5)‡ |
| DFLNH2 | 235.4 (145.7) | 41.0 (49.7) | −160.7 (183.6)‡ |
| DFLNT2 | 1219.8 (1157.9) | 901.8 (688.6) | −260.2 (354.5)† |
| DSLNH2 | 191.9 (160.0) | 43.6 (54.8) | −127.5 (137.8)‡ |
| DSLNT2 | 247.0 (244.7) | 183.7 (133.7) | −51.5 (125.3)§ |
| FDSLNH2 | 84.8 (61.4) | 45.3 (39.4) | −40.3 (53.2)† |
| FLNH | 66.9 (77.0) | 68.0 (35.8) | 8.3 (88.8) |
| LNFPI | 971.4 (1,537.2) | 437.9 (181.5) | −436.0 (708.8)† |
| LNFPII2 | 1340.1 (1111.9) | 1616.1 (1459.0) | 342.8 (586.2)† |
| LNFPIII2 | 71.1 (46.6) | 161.4 (99.0) | 93.4 (120.2)‡ |
| LNnT | 39.2 (32.1) | 105.3 (65.9) | 55.6 (78.2)† |
| LNT2 | 1422.6 (1250.7) | 1226.5 (1043.1) | −436.2 (522.2)‡ |
| LSTb2 | 96.2 (97.6) | 148.9 (165.7) | 35.5 (74.6) |
| LSTc | 206.0 (136.3) | 76.8 (57.6) | −131.7 (123.0)‡ |
| Sum | 11,285.8 (2555.1) | 10,408.1 (1645.6) | −877.6 (1403.3)† |
| Diversity | 5.14 (1.18) | 5.20 (1.29) | 0.06 (0.80) |
| Evenness | 0.32 (0.07) | 0.33 (0.08) | 0.004 (0.05) |
1
Values are medians (IQRs) when variables were not normally distributed for the 25 mothers included in this study. Paired t test on the change or log change (where noted) from ages 1 to 6 mo. ‡P < 0.0001, §P ≤ 0.002, †P ≤ 0.005. DFLNH, difucosyl-lacto-N-hexaose; DFLNT, difucosyl-lacto-N-tetraose; DSLNH, disialyl-lacto-N-hexaose; DSLNT, disialyl-lacto-N-tetraose; FDSLNH, fucosyl-disialyl-lacto-N-hexaose; FLNH, fucosyl-lacto-N-hexaose; LNFP, lacto-N-fucopentaose; LNnT, lacto-N-neotetraose; LNT, lacto-N-tetraose; LST, sialyl-lacto-N-tetraose; 2′-FL, 2′-fucosyllactose; 3-FL, 3-fucosyllactose; 3′-SL, 3′-sialyllactose.
2
Log changes are shown.