Table 1.
Baseline Demographic and Clinical Characteristics of Study Participants Stratified by Tenofovir Exposure.a
| Characteristics | Strata | All Patients, N = 4897 | TDF-Exposed (a), n = 2104 (43%) | TDF-Unexposed (b), n = 2793 (57%) | P Value, (a) versus (b) |
|---|---|---|---|---|---|
| Sex | Female | 2969 (60.63) | 1188 (40.01) | 1781 (59.99) | <.001b |
| Male | 1928 (39.37) | 916 (47.51) | 1012 (52.49) | ||
| Age range | ≤50 | 3715 (75.91) | 1642 (44.2) | 2073 (55.8) | .002b |
| >50 | 1179 (24.09) | 460 (39.02) | 719 (60.98) | ||
| Age, years | Median (IQR) | 42 (36-49) | 41 (35-48) | 42 (36-50) | <.001c |
| Weight, kg | Median (IQR) | 53 (61-70) | 60 (52-70) | 60 (53-69) | .334c |
| Hepatitis B or C | No | 2163 (72.61) | 675 (31.21) | 1488 (68.79) | <.001b |
| Yes | 816 (27.39) | 358 (43.87) | 458 (56.13) | ||
| WHO clinical stage | 1 or 2 | 2168 (68.41) | 638 (29.43) | 1530 (70.57) | <.001b |
| 3 or 4 | 1001 (31.59) | 432 (43.16) | 569 (56.84) | ||
| Viral load, copies/mL | ≤10 000 | 2804 (67.02) | 1092 (38.94) | 1712 (61.06) | .120b |
| >10 000 | 1380 (32.98) | 572 (41.45) | 808 (58.55) | ||
| Log10 | 3.5 (4.6-5.2) | 3.64 (4.59-5.28) | 3.45 (4.52-5.18) | .002c | |
| CD4 cells/mm3 | ≤100 | 1316 (27.04) | 586 (44.53) | 730 (55.47) | .154b |
| >100 | 3550 (72.96) | 1500 (42.25) | 2050 (57.75) | ||
| Median (IQR) | 94 (182-298) | 91 (188-319) | 95 (180-284.25) | .731c | |
| Creatinine (mmol/L) | Median (IQR) | 64 (80-103) | 74.05 (59-92.91) | 83 (66-106) | <.001c |
| CrCl, (mL/min) | Median (IQR) | 62 (82-104) | 97.73 (76.2-126.3) | 87.26 (66.4-112.2) | <.001c |
| eGFR (mL/min/1.73 m2) | Median (IQR) | 70 (92-118) | 102.48 (80.2-130.7) | 88.07 (66.4-112.4) | <.001c |
Abbreviations: CrCl, creatinine clearance; eGFR, estimated glomerular filtration rate; IQR, interquartile range; TDF, tenofovir disoproxil fumarate; WHO, World Health Organization.
a The number in parenthesis is percentages except indicated otherwise.
b The comparison was by χ2 for categorical variables.
c Mann-Whitney U test was used for comparison of median values.