Table 3.
Paired Hypoparathyroid Samples Before and After Long-Term rhPTH(1–84) ± SD
| Hypo-BL | Hypo-LT | P-value | |
|---|---|---|---|
| Bone structure | n = 8 | n = 8 | |
| BV/TV % | 19.6±5.0 | 29.1±11.0 | 0.017 |
| Tb.Wi µm | 111.7±22.0 | 115.9±21.0 | 0.48 |
| Tb.N #/mm | 1.8±1.0 | 2.5±1.0 | 0.025 |
| Tb.Sp µm | 474.0±117.0 | 321.4±145 | 0.025 |
| Ct.Wi µm | 1162.3±640.0 | 967.2±347 | 0.67 |
| Cortical porosity % | 6.3±5.0 | 9.5±3.0 | 0.07 |
| Bone remodeling | n = 13 | n = 13 | |
| Cancellous envelope | |||
| O.Wi Lamellar# | 1.9±1.0 | 4.3±1.0 | 0.017 |
| OS/BS % | 3.3±3.0 | 10.8±6.0 | 0.011 |
| MS/BS % | 0.3±1.0 | 7.9±7.0 | 0.003 |
| MAR µm/day | 0.4±1.0 | 0.6±1.0 | 0.284 |
| BFR/BS Mm/µm2/day | 0.003±0.01 | 0.047±0.05 | 0.007 |
| Aj.AR µm/day | 0.2±1.0 | 0.4±1.0 | 0.161 |
| ES/BS % | 4.6±2.0 | 7.5±3.0 | 0.021 |
| Endocortical envelope | |||
| O.Wi Lamellar# | 1.9±1.0 | 3.5±2.0 | 0.016 |
| OS/BS % | 10.5±11 | 13.7±9.0 | 0.20 |
| MS/BS % | 1.4±2.0 | 11.0±12.0 | 0.005 |
| MAR µm/day | 0.5±1.0 | 0.5±1.0 | 0.225 |
| BFR/BS Mm/µm2/day | 0.012±0.02 | 0.070±0.07 | 0.011 |
| Aj.AR mm/day | 0.3±1.0 | 0.4±1.0 | 0.345 |
| ES/BS % | 5.1±3.0 | 9.7±5.0 | 0.014 |
| Intracortical envelope | |||
| O.Wi Lamellar# | 2.7±1.0 | 4.0±1.0 | 0.004 |
| OS/BS % | 5.8±5.0 | 11.1±7.0 | 0.028 |
| MS/BS % | 3.1±4.0 | 11.3±8.0 | 0.004 |
| MAR µm/day | 0.8±1.0 | 0. 7±1.0 | 0.26 |
| BFR/BS Mm/µm2/day | 0.035±0.05 | 0.078±0.06 | 0.033 |
| Aj.AR µm/day | 1.0±1.0 | 0.7±1.0 | 0.59 |
| ES/BS % | 2.6±2.0 | 7.1±4.0 | 0.006 |
Hypo-BL = hypoparathyroid baseline; Hypo-LT = hypoparathyroid long-term; BV/TV = trabecular bone volume; Tb.Wi = trabecular width; Tb.N = trabecular number; Tb.Sp = trabecular separation; Ct.Wi = cortical width; O.Wi = osteoid width; OS/BS = osteoid surface; MS/BS = mineralizing surface; MAR = mineral apposition rate; BFR/BS = bone formation rate; AjAR = adjusted apposition rate; ES/BS = eroded surface.
Bold indicates significance at p < 0.05.