Table 4.
Hypoparathyroid Samples: Long-Term Versus Control Samples ± SD
| Hypo-LT (n = 13) | Matched control-LT (n = 13) | P-value Hypopara-LT vs matched control-LT | Control (n = 45) | P-value Hypopara-LT vs control adjusted for age and gender | |
|---|---|---|---|---|---|
| Age, years (range) |
52.9±16.0 (32–79) |
52.3±12.0 (34–71) |
0.18 | 50.4±13.0 (20–71) |
|
| Gender (n) | 1.0 | ||||
| Male | 4 | 4 | 11 | ||
| Premenopausal | 5 | 5 | 17 | ||
| Postmenopausal | 4 | 4 | 17 | ||
| Bone structure | |||||
| BV/TV % | 29.2±9.0 | 19.0±6.0 | 0.007 | 19.8±5.0 | <0.001 |
| Tb.Wi µm | 114. 9±20.0 | 115.0±26.0 | 0.76 | 114.8±20.0 | 0.94 |
| Tb.N #/mm | 2.5±1.0 | 1.6±1.0 | <0.001 | 1.7±1.0 | <0.001 |
| Tb.Sp µm | 308.3±120.0 | 530.9±182.0 | <0.001 | 484.7±131.0 | <0.001 |
| Ct.Wi µm | 851.05±327.0 | 676.1±207.0 | 0.14 | 748.4±247.0 | 0.23 |
| Cortical porosity % | 10.0±3.0 | 8.1±4.0 | 0.044 | 7.4±4.0 | 0.036 |
| Bone remodeling | |||||
| Cancellous envelope | |||||
| O.Wi Lamellar# | 4.3±1.0 | 4.1± 2.0 | 0.92 | 4.1±1.0 | 0.54 |
| OS/BS % | 10.8±6.0 | 8.9±6.0 | 0.45 | 7.2±4.0 | 0.023 |
| MS/BS % | 7.9±7.0 | 4.5±4.0 | 0.39 | 4.3±3.0 | 0.012 |
| MAR mm/day | 0.6±1.0 | 0.7±1.0 | 0.09 | 0.7±1.0 | 0.044 |
| BFR/BS | 0.047±0.05 | 0.034±0.03 | 0.61 | 0.033±0.03 | 0.112 |
| Mm/µm2/day | |||||
| Aj.AR µm/day | 0.4±1.0 | 0.3±1.0 | 0.76 | 0.5±1.0 | 0.362 |
| ES/BS % | 7.5±3.0 | 4.3±2.0 | 0.002 | 4.2±2.0 | <0.001 |
| Endocortical envelope | |||||
| O.Wi Lamellar# | 3.5±2.0 | 3.3±1.0 | 0.76 | 3.2±1.0 | 0.44 |
| OS/BS, % | 13.7±9.0 | 15.1±7.0 | 0.61 | 12.6±7.0 | 0.64 |
| MS/BS % | 11.0±12.0 | 9.9±7.0 | 0.92 | 9.9±10.0 | 0.72 |
| MAR µm/day | 0.5±1.0 | 0.7±1.0 | 0.12 | 0.7±1.0 | 0.066 |
| BFR/BS | 0.070±0.07 | 0.077±0.06 | 0.35 | 0.077±0.08 | 0.903 |
| Mm/µm2/day | |||||
| Aj.AR µm/day | 0.4±1.0 | 0.5±1.0 | 0.98 | 0.8±2.0 | 0.48 |
| ES/BS % | 9.7±5.0 | 5.9±3.0 | 0.029 | 6.4±4.0 | 0.015 |
| Intracortical envelope | |||||
| O.Wi Lamellar# | 4.0±1.0 | 3.6±1.0 | 0.42 | 3.4±1.0 | 0.195 |
| OS/BS % | 11.1±7.0 | 9.4±6.0 | 0.48 | 10.2±7.0 | 0.720 |
| MS/BS % | 11.3±8.0 | 8.9±6.0 | 0.58 | 9.4±8 | 0.431 |
| MAR µm/day | 0.7±1.0 | 0.9±1.0 | 0.06 | 0.8±1.0 | 0.238 |
| BFR/BS | 0.078±0.06 | 0.090±0.07 | 0.92 | 0.088±0.08 | 0.723 |
| Mm/µm2/day | |||||
| Aj.AR µm/day | 0.7±1.0 | 1.0±1.0 | 0.29 | 1.1±1.0 | 0.482 |
| ES/BS % | 7.1±4.0 | 4.5±4.0 | 0.057 | 4.6±4.0 | 0.015 |
Hypo-BL = hypoparathyroid baseline; Hypo-LT = hypoparathyroid long-term; Matched Control-LT = matched control long-term; BV/TV = trabecular bone volume; Tb.Wi = trabecular width; Tb.N = trabecular number; Tb.Sp = trabecular separation; Ct.Wi = cortical width; O.Wi = osteoid width; OS/ BS = osteoid surface; MS/BS = mineralizing surface; MAR = mineral apposition rate; BFR/BS = bone formation rate; AjAR = adjusted apposition rate; ES/ BS = eroded surface.
Bold indicates significance at p < 0.05.