. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Pharmacogenet Genomics. 2019 Jul;29(5):99–105. doi: 10.1097/FPC.0000000000000371

Table 2.

Kinetic parameters of wild-type and SULT1A3 allozymes with salbutamol as substrate.

SULT1A3 allozymes	K_m (μM)	V_max (nmol/min/mg)	V_max/K_m (nmol/min/mg/μM)
1A3-WT¹	54.07 ± 3.47	34.27 ± 1.29	0.63
1A3-T7P	71.83 ± 5.87	29.56 ± 0.50	0.49
1A3-S8P	172.00 ± 19.23	11.89 ± 0.31	0.07
1A3-R9C	243.00 ± 43.92	32.26 ± 1.51	0.13
1A3-P10L	88.50 ± 9.05	30.47 ± 0.66	0.34
1A3-V15M	173.20 ± 31.58	28.90 ± 1.26	0.17
1A3-V18F	118.80 ± 18.52	25.74 ± 0.90	0.22
1A3-P101L	90.77 ± 8.70	24.05 ± 0.49	0.26
1A3-P101H	54.26 ± 4.29	33.40 ± 0.51	0.62
1A3-R144C	57.75 ± 5.51	35.25 ± 0.66	0.61
1A3-K234N	107.10 ± 13.83	24.30 ± 0.69	0.23
1A3-N235T	386.30 ± 45.86	28.06 ± 1.85	0.07
1A3-S290T	87.78 ± 9.04	30.76 ± 0.67	0.35

Wild-type human SULT1A3.