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. 2019 Apr 25;16(7):918–929. doi: 10.1080/15476286.2019.1600999

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Mitofusin-2 down-regulation by miR-195 changes mitochondrial morphology and promote mitochondrial fission.

Mitochondria become rounded, small and fragmented upon up-regulation of miR-195 and gets tubular in shape upon treatment of MFN2 along with miR-195 and Mdivi-1 treatment in (a) MCF-7 cells and (b) MDAMB-231 cells. Bar: 100 µm. The mean branch length of mitochondria reduces upon miR-195 treatment and restored back upon treatment of MFN2 along with miR-195 and Mdivi-1 treatment in (c)MCF-7 and (d)MDAMB-231, mean branch length ±SE for n = 3 was plotted, *: p< 0.05, ***: p< 0.001.