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. 2019 Apr 25;16(7):918–929. doi: 10.1080/15476286.2019.1600999

Figure 8.

Figure 8.

Schematic diagram showing miR-195 mediated mitochondrial functional impairment via MFN2.

MiR-195 affects mitochondrial dynamics by blocking MFN2 mediated mitochondrial fusion. The fragmented mitochondria as a result of miR-195 over-expression are metabolically less active with repairable oxidative stress.