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HuR does not regulate IL-2 and TNF levels through their 3′ UTR. (a) Activity of luciferase reporters containing cytokine mRNA 3′ UTRs measured in WT and HuR KO T-REx-293 cells, n = 2. (b) Activity of IL-2 and TNF 3′ UTR reporters in WT, HuR KO1 and HuR KO2 Jurkat cells in resting and activated states, n = 3. Renilla luciferase activity was normalized to co-expressed firefly luciferase activity and to empty (no 3′ UTR) control reporters.
