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. 2019 Apr 21;16(7):940–949. doi: 10.1080/15476286.2019.1602436

Figure 1.

Figure 1.

The expression levels of SLC47A2 and SANT1 in RCC tissues were significantly lower than in paired adjacent tissues. (a) The abundance of the SLC47A2 mRNA was strongly reduced in tumour tissues and the expression levels were normalized to GAPDH level (n = 8). (b) The protein levels of MATE 2-K in three RCC tissues (RC) and paired adjacent non-tumour (RN) tissues; the expression levels were normalized to GAPDH level. (c) Kaplan–Meier curves were used to determine the survival probability. Low SLC47A2 expression indicated poor prognosis in kidney renal clear cell carcinoma (p = 0.0046) and kidney renal papillary cell carcinoma (p = 0.0046). (d) The UCSC genome browser revealed the locations of the promoters (P1-P4) and transcription factor (TF) binding sites (S1-S3) in the SLC47A2 locus. The expression levels of non-mRNA transcripts (site A-E) were detected using qPCR. (e) Higher binding levels of S-5-P RNAPII on sections 1 and 3 indicated higher expression levels of mRNA and SANT in adjacent tissue (R39N) than in RCC tissue (R39C). All the data were normalized to the RNAP II binding values in GAPDH promoter. (f) Transcript abundance in the downstream regulatory regions of the SLC47A2 locus. (g) The transcript abundances of SANT1 was strongly reduced in tumor tissues and the expression levels were normalized to that of GAPDH (n = 8).