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SANT1 altered the binding of SFPQ/E2F1/HDAC1 to the coding gene promoter. (a) Formation of the transcription suppressor SFPQ/E2F1/HDAC1 complex. (b) The perfect secondary structure of SANT1 is necessary for the formation of a functional RNP complex. (c) High expression of SANT1 promotes H3K27ac modification and S-5-P RNAPII binding to the SLC47A2 promoter by inducing off-target binding of E2F1/HDAC1 to the coding gene promoter.
