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. 2018 May 21;16(4):469–480. doi: 10.1080/15476286.2018.1460994

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — The H. volcanii CRISPR-Cas I-B system. (a) The composition and configuration of its cas gene cassette (purple) characterizes the H. volcanii CRISPR-Cas system as subtype I-B. The cas gene cassette on the chromosomal plasmid pHV4 is flanked by two of the three H. volcanii CRISPR loci (P1 and P2). The third locus (C) is encoded on the main chromosome. Each CRISPR locus encompasses unique spacer sequences (boxes) interspersed by repeat elements (diamonds). Transcription of the CRISPR loci is governed by their individual leader sequence containing the promoter elements and gives rise to the crRNAs needed for the specificity of CRISPR Cas immunity. (b) The sequence of all three H. volcanii repeat elements is identical in all but one nucleotide (red).