Table 1.
Parameters Used in COMSOL Model of BMP-2 Release in Femoral Defect
| Category | Parameter | Value | Reference |
|---|---|---|---|
| Dimensions | Diameter of Alginate Cylinder | 4.5 mm | |
| Length of Alginate Cylinder | 10 mm | ||
| Diameter of Thigh Cylinder | 15 mm | ||
| Length of Thigh Cylinder | 18 mm | ||
| BMP-2 Diffusion Through Alginate | Effective Diffusion Coefficient (DBMP,Alg) | 1.7E-06 cm2/s | |
| BMP-2 Diffusion Through Thigh | Effective Diffusion Coefficient (DBMP,Tiss) | 2.0E-08 cm2/s | [18] |
| BMP-2 Interactions with HMPs | Weight of HMPs | 0.1 mg, 1 mg | |
| Number of HMPs | 2.0E06, 2.0E07 | ||
| Number of Binding Sites | 7.0E14, 7.0E15 | ||
| Number of BMP-2 Molecules | 5.8E13 | ||
| Dissociation Constant (KD) | 50 nM | Adapted from [40] | |
| Dissociation Rate Constant (kon) | 5.1E-04 1/nM•s | Adapted from [40] | |
| Association Rate Constant (koff) | 0.25 1/s | Adapted from [40] | |