Comparison 4. Combination versus antidepressant (AD) alone: remission in depression.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Early phase (2 weeks, range 1–4 weeks)	10	731	Risk Ratio (IV, Random, 95% CI)	1.39 [1.03, 1.90]
1.1 Short‐acting hypnotics	2	153	Risk Ratio (IV, Random, 95% CI)	1.18 [0.47, 2.92]
1.2 Anxiolytics or long‐acting hypnotics	9	578	Risk Ratio (IV, Random, 95% CI)	1.45 [0.97, 2.18]
2 Acute phase (8 weeks, range 5–12 weeks)	7	383	Risk Ratio (IV, Random, 95% CI)	1.27 [0.99, 1.63]
2.1 Short‐acting hypnotics	1	27	Risk Ratio (IV, Random, 95% CI)	2.63 [0.14, 49.69]
2.2 Anxiolytics or long‐acting hypnotics	7	356	Risk Ratio (IV, Random, 95% CI)	1.26 [0.96, 1.65]
3 Continuous phase (> 12 weeks)	1	52	Risk Ratio (IV, Random, 95% CI)	1.31 [0.80, 2.16]
3.1 Anxiolytics or long‐acting hypnotics	1	52	Risk Ratio (IV, Random, 95% CI)	1.31 [0.80, 2.16]