Comparison 6. Combination versus antidepressant (AD) alone: adverse effects.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Dropouts due to adverse effects	10	731	Risk Ratio (IV, Random, 95% CI)	0.54 [0.32, 0.90]
1.1 Short‐acting hypnotics	2	153	Risk Ratio (IV, Random, 95% CI)	0.54 [0.24, 1.21]
1.2 Anxiolytics or long‐acting hypnotics	9	578	Risk Ratio (IV, Random, 95% CI)	0.56 [0.28, 1.11]
2 Number of participants with ≥ 1 adverse effect	7	510	Risk Ratio (IV, Random, 95% CI)	1.12 [1.01, 1.23]
2.1 Anxiolytics or long‐acting hypnotics	7	510	Risk Ratio (IV, Random, 95% CI)	1.12 [1.01, 1.23]