Comparison 7. Subgroup analysis: severity of comorbid anxiety.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Depression severity, early phase (2 weeks, range ranged 1–4 weeks)	2	109	Std. Mean Difference (IV, Random, 95% CI)	‐0.11 [‐0.52, 0.29]
1.1 Moderate‐to‐severe anxiety	1	62	Std. Mean Difference (IV, Random, 95% CI)	‐0.29 [‐0.79, 0.21]
1.2 Mild‐to‐moderate anxiety	1	47	Std. Mean Difference (IV, Random, 95% CI)	0.12 [‐0.45, 0.70]
2 Depression severity, acute phase (8 weeks, range 5–12 weeks)	2	109	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.53, 0.22]
2.1 Moderate‐to‐severe anxiety	1	62	Std. Mean Difference (IV, Random, 95% CI)	‐0.32 [‐0.82, 0.18]
2.2 Mild‐to‐moderate anxiety	1	47	Std. Mean Difference (IV, Random, 95% CI)	0.06 [‐0.51, 0.64]