Feighner 1979.

Methods	Type of trial: parallel Randomised: yes Allocation concealment: yes Double‐blinding: yes Study quality: high Duration of treatment: 4 weeks Cointervention: not available
Participants	Setting: psychiatric OP Diagnosis: definite primary depression (Feighner), with moderate‐to‐severe anxiety Age (mean): 40.6 years Men/women: 66/124 Baseline depressive severity (mean): 35.2 (SD 8.8) on HRSD‐24 Baseline anxiety severity: moderate/severe
Interventions	Amitriptyline 75–150 mg + chlordiazepoxide 30–60 mg
Outcomes	HRSD‐24, CGI up to 4 weeks
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Participants randomised, but no details provided on how random sequence generated.
Allocation concealment (selection bias)	Unclear risk	Details of allocation concealment not reported.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "this multicenter, double‐blind, placebo‐controlled study". Further details not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Details of outcome assessor blinding not reported.
Incomplete outcome data (attrition bias) All outcomes	High risk	Large proportion of participants (18/97 of intervention group and 23/93 of control group) excluded from the analysis.
Selective reporting (reporting bias)	Unclear risk	Study protocol not available; thus, unsure if all of prespecified outcomes of interest reported in prespecified way.
Other bias	Unclear risk	Insufficient information to assess other bias.