Scharf 1986.

Methods	Type of trial: parallel Randomised: yes Allocation concealment: unclear Double‐blinding: yes Study quality: intermediate Duration of treatment: 8 weeks Cointervention: not available
Participants	Setting: psychiatric Diagnosis: "clinically depressed based on DSM‐III" Age (mean): 34.8 (SD 11.7) years Men/women: 10/10 Baseline depressive severity (mean): 24.3 (SD 5.4) on HRSD Baseline anxiety severity: not available
Interventions	Amitriptyline 50–150 mg + chlordiazepoxide 20–60 mg
Outcomes	HRSD, State Anxiety Scale up to 8 weeks
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Participants randomised, but no details on how random sequence generated.
Allocation concealment (selection bias)	Unclear risk	Details of allocation concealment not reported.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "double‐blind, randomized comparison". Further details not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Details of outcome assessor blinding not reported.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No dropouts
Selective reporting (reporting bias)	Unclear risk	Study protocol not available; thus, unsure if all of prespecified outcomes of interest reported in prespecified way.
Other bias	Unclear risk	Insufficient information to assess other bias.