Smith 2002.

Methods	Type of trial: parallel Randomised: yes Allocation concealment: unclear Double‐blinding: yes Study quality: intermediate Duration of treatment: 12 weeks Cointervention: not available
Participants	Setting: psychiatric OP Diagnosis: non‐psychotic major depressive disorder (DSM‐IV), not precipitated by life stressors Age (mean): 41.1 years Men/women: 25/25 Baseline depressive severity (mean): 22.4 on HRSD‐17 Baseline anxiety severity: 58% of participants were described as "aroused."
Interventions	Fluoxetine 20–40 mg + clonazepam 0.5–1 mg
Outcomes	HRSD‐17, CGI up to 18 weeks
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Participants randomised, but no details on how random sequence generated.
Allocation concealment (selection bias)	Unclear risk	Details of allocation concealment not reported.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "using a traditional double‐blind parallel group design." Further details not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Details of outcome assessor blinding not reported.
Incomplete outcome data (attrition bias) All outcomes	High risk	Dropout was a large proportion (13/27 of intervention group and 5/25 of control group) and detail of imputing method not reported.
Selective reporting (reporting bias)	Unclear risk	Study protocol not available; thus, unsure if all of prespecified outcomes of interest reported in prespecified way
Other bias	Unclear risk	Insufficient information to assess other bias.