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. 2019 Apr 29;129(6):2266–2278. doi: 10.1172/JCI66062

Figure 3. Hepatic overexpression of Klf9 elevates blood glucose and impairs glucose tolerance in C57BL/6J mice.

Figure 3

(A) Quantitative PCR analysis of Klf9, Pgc1a, G6pc, Pck1, and Glut2 in the livers of C57BL/6J mice infected with Ad-GFP or Ad-Klf9 (n = 6/group). Seven days after infection, the 6 hour–fasted mice were sacrificed for further analysis. (B) Representative Western blot analysis of the hepatic KLF9 and PGC1α in mice treated as in A. (C) Blood glucose of 6 hour–fasted C57BL/6J mice treated as in A on day 7 after adenovirus injection. (D, E) Blood glucose during the GTT (D) and PTT (E) of C57BL/6J mice treated as in A (n = 6/group). Data are represented as mean ± SEM. *P < 0.05; **P < 0.01, 2-tailed Student’s t test (A, C-E).