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. 2019 May 20;129(6):2542–2554. doi: 10.1172/JCI126859

Figure 7. AMPA receptor antagonist NBQX does not block the antidepressant actions of NV-5138.

Figure 7

(A) Rats were administered either vehicle (0.5% DMSO, 1 ml/kg, i.p.) or NBQX (10 mg/kg, i.p.) 30 minutes prior to administration of vehicle or NV-5138 (160 mg/kg, p.o.). Twenty-four hours after NV-5138 administration, behavioral studies were initiated and performed over the next 3 days. (B and D) NV-5138 treatment significantly decreased immobility time (B) and latency to feed (D), but these effects were not blocked by pretreatment with NBQX in the FST (effect of treatment: F2,21 = 18.5, P < 0.001) and NSFT (effect of treatment: F2,19 = 56.5, P < 0.001), respectively. (C and E) No significant effects were observed in LMA (effect of treatment: F2,21 = 0.304, P > 0.05) or HCF (effect of treatment: F2,21 = 0.625, P > 0.05). Results are shown as mean ± SEM. n = 7–8/group. ***P < 0.001 compared with control group, 1-way ANOVA followed by post hoc Tukey’s multiple comparison test.