Skip to main content
. 2019 May 13;129(6):2463–2479. doi: 10.1172/JCI125301

Figure 9. MMP-9 pathway DEGs are linked to a variety of renal diseases, cancers, microbial infections, and immune activation.

Figure 9

MMP-9 pathways associated ptPBL DEGs from pathDIP matrix were correlated, and DEGs significantly associated with MMP-9 pathways (P < 0.05) were used to generate a supervised heatmap of the most highly correlating MMP-9 pathway genes and associated pathways. The majority of FIR DEG–associated MMP-9 pathways are enriched for those of renal diseases; numerous viral, bacterial, and parasitic infections; numerous cancers; immunity and antigen recognition and activation; differentiation; and cellular survival pathways. The orange area shows DEGs represented in the pathway; blue shows DEGs not represented in the pathway (see Supplemental Figure 9 for the full list of DEG pathways).