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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Semin Thromb Hemost. 2019 May 16;45(4):385–395. doi: 10.1055/s-0039-1687894

Figure 3.

Figure 3

Proposed mechanisms of tumor tissue factor (TF) and thrombin-dependent tumor growth. (A) The full-length TF/factor (F) VIIa complex binds to integrin β1 and the TF/FVIIa/ integrin β1 complex activate protease activated receptor (PAR)2. PAR2 activates phosphatidylinositol- 3-kinase (PI3 kinase) and mitogen activated protease (MAP) kinase signalings resulting in tumor growth. (B) Thrombin activates PAR1 that has both positive and negative role in tumor growth. (C) Alternative spliced (as) TF is released from tumor cells and binds to integrin α6β1. This asTF/integrin α6β1complex contributes to tumor growth via PI3 and MAP kinases. Cells and proteins were modified from Servier Medical Art, licensed under Creative Common Attribution 3.0 Unported License. (http://www.servier.fr/servier-medical-art)